Order Silenor (doxepin) online from licensed U.S. pharmacies

Product Name	Silenor
Dosage	3 mg, 6 mg
Active Ingredient	Doxepin
Form	Oral Tablets
Description	FDA‑approved prescription medicine for adults with insomnia characterized by difficulty maintaining sleep during the night.
How to Order Without Prescription	A valid U.S. prescription is required. Many online services provide a quick telehealth evaluation that can issue an e‑prescription if appropriate.

Silenor is a modern, low‑dose form of doxepin specifically formulated to help adults stay asleep through the night. Unlike older sedatives, Silenor targets histamine H1 receptors at doses of 3 mg and 6 mg, which supports sleep maintenance with a low risk of next‑day grogginess when taken as directed. In the United States, Silenor is a prescription medication. Patients can obtain Silenor through their healthcare provider or via a licensed U.S. telehealth service that can review symptoms and prescribe online when clinically appropriate.

Doxepin has been used in medicine for decades, but its low‑dose formulation for insomnia is relatively recent. Silenor tablets are designed for bedtime use and are not habit‑forming, not scheduled as a controlled substance, and can be taken for short‑term or longer‑term management of chronic sleep maintenance insomnia under a clinician’s guidance. Generic doxepin tablets in 3 mg and 6 mg strengths are also available in the USA and often provide a more affordable option with the same active ingredient and efficacy.

Silenor cost and typical U.S. pricing

Costs for Silenor in the United States vary by pharmacy, dosage, quantity, and whether you use brand or generic doxepin 3 mg/6 mg. Insurance coverage, deductibles, and discount cards can further influence out‑of‑pocket costs. While pricing changes frequently, the following examples illustrate common patterns patients may see at retail and mail‑order pharmacies:

A 30‑tablet supply of Silenor 3 mg may be priced higher than the generic version; however, pharmacy coupons and insurance may significantly reduce your final cost. Many patients opt for generic doxepin 3 mg, which can markedly lower the per‑tablet price. Ordering a 60‑tablet or 90‑tablet quantity often provides a better per‑unit value than smaller fills.

Silenor 6 mg tablets are typically more expensive than 3 mg, reflecting the higher dose. Generic 6 mg doxepin can be substantially more cost‑effective. If your clinician prescribes 3 mg but you respond well, they may choose to maintain that dose to help control costs while meeting your sleep goals.

Mail‑order pharmacies and subscription services may offer competitive monthly pricing, automatic refills, and delivery reminders. Always compare prices, and ask your prescriber if generic doxepin is appropriate—it contains the same active ingredient and is FDA‑approved to work the same way as the brand‑name product.

Where can I buy Silenor in the USA?

If you are seeking Silenor in the United States, you can obtain it through local retail pharmacies, reputable mail‑order pharmacies, or licensed online pharmacies that serve U.S. patients. Because Silenor is prescription‑only, you’ll need an active prescription from a U.S. clinician. Many patients find it convenient to complete a brief online telehealth evaluation; when appropriate, the clinician can send an electronic prescription to a partner pharmacy for home delivery.

We collaborate with well‑known pharmacy networks and encourage patients to use lawful, U.S.‑licensed channels for Silenor. This ensures medication authenticity, proper counseling, and access to pharmacists for questions. Our goal is to make the process simple, safe, and compliant with U.S. regulations, while helping you get the sleep support you need.

Online ordering is especially helpful for patients who prefer not to travel, have busy schedules, or want discreet delivery. Whether you choose brand‑name Silenor or generic doxepin, you can count on reliable fulfillment, tracking, and professional support.

Silenor availability across the United States

Low‑dose doxepin for insomnia is widely available across the U.S. Most major chains and independent pharmacies can fill Silenor or its generic. If your preferred pharmacy does not have it in stock, they can typically order it within 1–2 business days. For the smoothest experience, provide your prescriber with your preferred pharmacy information and confirm stock before your first fill. Many telehealth services integrate with nationwide pharmacy networks to streamline prescribing and delivery.

What is Silenor (doxepin)?

Silenor is a prescription sleep medication for adults who have trouble staying asleep during the night. Its active ingredient, doxepin, is a tricyclic compound that, at low doses (3 mg and 6 mg), primarily blocks histamine H1 receptors in the brain’s wakefulness pathways. By reducing histamine‑related arousal, Silenor promotes longer, more consolidated sleep without relying on traditional sedative‑hypnotic mechanisms.

Unlike benzodiazepines or “Z‑drugs,” Silenor is not a controlled substance and is not known to cause dependence when used as directed. It can be suitable for patients who mainly struggle with frequent awakenings or early‑morning wakefulness. Silenor is taken once nightly within 30 minutes of bedtime. For best effect, avoid taking it within three hours of a meal, as a high‑fat or late meal may increase the risk of next‑day drowsiness.

Although doxepin has been used at much higher doses for depression and anxiety, Silenor’s low‑dose formulation selectively targets sleep maintenance with a favorable safety profile. Always use Silenor under the guidance of a licensed healthcare professional who can determine if it is appropriate for your specific sleep pattern and medical history.

How Silenor helps sleep maintenance insomnia

Sleep maintenance insomnia often involves frequent nighttime awakenings or waking too early and being unable to return to sleep. Histamine is a key neurotransmitter involved in promoting wakefulness. Silenor’s low‑dose doxepin blocks histamine H1 receptors, helping dampen the wake drive so you can stay asleep longer. Clinical trials have shown improvements in objective and subjective measures of wake time after sleep onset and total sleep time in adults with insomnia who took Silenor versus placebo.

Because Silenor’s target is histamine signaling, many patients experience fewer issues with next‑day impairment compared with traditional sedatives. Nevertheless, any sleep medication can cause residual drowsiness in some individuals, so it is important to take Silenor exactly as directed and to assess your alertness the next morning before driving or operating machinery.

For people whose main difficulty is falling asleep (sleep onset insomnia), a different treatment strategy may be warranted. Your clinician can help you decide whether Silenor alone is appropriate or if behavioral therapy for insomnia (CBT‑I), sleep hygiene measures, or another medication class should be incorporated.

Why low‑dose doxepin matters

At the low doses used in Silenor (3 mg, 6 mg), doxepin exhibits strong H1 antagonism with minimal effects on norepinephrine and serotonin reuptake that are seen at antidepressant doses. This receptor selectivity contributes to its sleep maintenance benefits while limiting anticholinergic and cardiovascular side effects commonly associated with higher‑dose tricyclic antidepressants. In real‑world use, this translates to a sleep aid that is generally well tolerated and suitable for long‑term management in many adults when clinically indicated.

Clinical evidence for Silenor

Multiple randomized, double‑blind, placebo‑controlled studies have evaluated low‑dose doxepin for insomnia. Across trials, Silenor improved sleep maintenance endpoints such as wake time after sleep onset (WASO), number of awakenings, and total sleep time—without significant next‑day psychomotor impairment at recommended doses. Efficacy has been demonstrated both in younger adults and in older adults, with the 3 mg dose often preferred in older individuals due to increased sensitivity to medications.

Importantly, Silenor did not show clinically relevant effects on QT interval at approved doses in thorough QT studies, and the risk of complex sleep behaviors appears low. As with any hypnotic, patients should be monitored for unusual sleep behaviors and next‑day drowsiness, especially when starting therapy or adjusting the dose.

Is Silenor habit‑forming or a controlled substance?

No. Doxepin at low doses is not classified as a controlled substance in the United States, and Silenor is not considered habit‑forming when used as prescribed. It does not share the same dependence potential as benzodiazepines or certain non‑benzodiazepine hypnotics. Nevertheless, always follow your prescriber’s instructions and avoid combining Silenor with alcohol or other central nervous system depressants.

Silenor vs. traditional doxepin capsules and other sleep aids

Conventional doxepin capsules used for depression or anxiety are typically dosed in tens of milligrams (e.g., 25–150 mg), leading to broader tricyclic effects and a different side‑effect profile. Silenor and low‑dose generic doxepin 3 mg/6 mg target sleep via H1 antagonism and are not interchangeable with high‑dose capsules used for mood disorders. Patients should not substitute higher‑dose doxepin products to treat insomnia unless directed by a clinician.

Compared with benzodiazepines and certain “Z‑drugs,” Silenor offers a non‑controlled, histamine‑focused approach that may better suit patients concerned about dependence or next‑day impairment. Melatonin receptor agonists and orexin receptor antagonists provide alternative mechanisms. Your clinician can help weigh pros and cons based on your specific symptoms, medical conditions, and medication list.

Who should not take Silenor

Silenor is not right for everyone. Do not take Silenor if you:

• are allergic to doxepin or any inactive ingredients in Silenor
• have untreated narrow‑angle glaucoma or severe urinary retention
• are currently taking, or have taken within the past 14 days, a monoamine oxidase inhibitor (MAOI)
• are unable to get a full night of sleep (at least 7–8 hours) before needing to be active again

Use caution and discuss risks and benefits with your clinician if you have sleep apnea, severe liver disease, bipolar disorder, a history of urinary retention, or are taking other medicines that may cause sedation, anticholinergic effects, or QT prolongation. Elderly patients may be more sensitive to the effects of sleep medications; 3 mg is often recommended as a starting dose in older adults.

Mechanism of action

At low doses, doxepin selectively antagonizes central histamine H1 receptors in the tuberomammillary nucleus and related wake‑promoting circuits. Histamine is a major neurotransmitter of arousal; blocking H1 reduces nighttime wakefulness and supports sleep maintenance. At these doses, doxepin has minimal activity at muscarinic, serotonergic, and adrenergic receptors relative to the much higher doses used as an antidepressant.

This mechanism differs from GABAergic hypnotics that enhance inhibitory neurotransmission. By sparing GABA pathways, Silenor may reduce risks tied to amnesia or complex sleep behaviors, although patients should still be monitored for unusual events with any hypnotic therapy.

Safety profile

In clinical and post‑marketing experience, low‑dose doxepin is generally well tolerated. The most frequently reported adverse effect is somnolence. Dry mouth, nausea, and dizziness occur less commonly. Because Silenor is taken at bedtime, many side effects present as next‑morning drowsiness if the dose is too high or if taken after a late, high‑fat meal. Adjusting dosing time and avoiding late meals can help minimize residual effects.

As with all antidepressants, doxepin carries a boxed warning regarding suicidal thoughts and behaviors in children, adolescents, and young adults with major depressive disorder and other psychiatric disorders. Although Silenor is not indicated for depression and uses very low doses, the class warning applies. Monitor for mood or behavior changes, and seek medical advice if new or worsening symptoms occur.

Silenor dosage for adults

The recommended adult dose of Silenor is 6 mg once nightly, taken within 30 minutes of bedtime. Many patients, especially older adults or those sensitive to medications, may start at 3 mg nightly. Your prescriber will help determine the best starting dose based on your age, comorbidities, and concurrent medications.

Do not take Silenor within 3 hours of a meal, as food—particularly a high‑fat meal—can increase drug exposure and the risk of next‑day drowsiness. Take Silenor only when you can commit to a full night of sleep (7–8 hours) before you need to be active again.

How to take Silenor correctly

Follow your prescriber’s instructions. In general:

• Take Silenor 30 minutes before bedtime.
• Avoid taking it within 3 hours of a meal to reduce next‑day drowsiness.
• Only take it when you can allow 7–8 hours for sleep.
• Do not combine with alcohol or other sedatives.

If your clinician recommends ongoing therapy, regular check‑ins can help assess effectiveness and minimize side effects. Do not increase the dose on your own. If you feel overly sedated, contact your prescriber; a dose adjustment or timing change may help.

Onset, duration, and next‑day alertness

Patients typically begin feeling the benefits of Silenor within the first few nights, with continued improvement over 1–2 weeks as sleep patterns stabilize. Silenor’s effect focuses on reducing nighttime awakenings and extending sleep duration. Most people do not experience significant next‑day impairment when the medication is taken as directed at 3 mg to 6 mg, especially if avoided within 3 hours of a meal and when a full night of sleep is possible.

Always assess how you feel the next morning. If you experience prolonged drowsiness, do not drive or operate heavy machinery, and consult your prescriber about dose adjustments.

Missed dose, overdose, and discontinuation

If you forget to take Silenor at bedtime, skip the missed dose and take your next dose at the usual time on the following night. Do not take Silenor in the middle of the night if there are fewer than 7–8 hours remaining before you need to be active.

Overdose risk is low at approved doses but can increase if combined with alcohol, sedatives, or certain interacting medications. Symptoms of overdose may include severe drowsiness, confusion, or agitation. If you suspect an overdose, seek emergency medical attention or contact Poison Control (1‑800‑222‑1222 in the USA).

Silenor does not typically require tapering at approved doses. If you plan to stop, discuss with your clinician, as insomnia may recur. Continuing good sleep hygiene and CBT‑I strategies can help sustain benefits.

How to use and store Silenor

Take Silenor by mouth exactly as prescribed. Store tablets at room temperature away from moisture and excessive heat. Keep out of reach of children and pets. Do not share prescription medications with others, even if they have similar symptoms.

Pregnancy and breastfeeding

Silenor should be used during pregnancy only if the potential benefit justifies the potential risk. There are limited data with low‑dose doxepin in pregnant women; discuss options with your clinician. If you are breastfeeding, consult your healthcare provider before use. Doxepin and its active metabolite can pass into breast milk, and rare cases of infant sedation and poor feeding have been reported with higher‑dose doxepin. Your clinician will weigh potential risks and benefits and may suggest alternative approaches for sleep.

Pharmacist’s tips for better sleep with Silenor

To get the most from Silenor, combine it with healthy sleep habits:

Go to bed and wake up at consistent times, keep your bedroom cool and dark, avoid screens and heavy meals 2–3 hours before bedtime, and limit caffeine after midday. If you consume alcohol, avoid it near bedtime. Regular exercise earlier in the day supports sleep quality, but intense workouts close to bedtime may be too stimulating.

Give Silenor enough time to work; some patients notice early improvement, while others need a week or two. If you still wake frequently, keep a sleep diary and share it with your prescriber to fine‑tune treatment. Never mix Silenor with alcohol or take it alongside other sedative medications unless your clinician has approved the combination.

Safety precautions

Do not take Silenor if you have untreated narrow‑angle glaucoma, severe urinary retention, or if you are using an MAOI or have used one in the past 14 days. Avoid alcohol while taking Silenor. Use caution if you have sleep apnea or severe liver impairment. Older adults should typically start at 3 mg under medical supervision.

If you experience mood changes, agitation, unusual sleep behaviors, confusion, or prolonged next‑day drowsiness, stop taking the medication and seek medical advice. Always let your care team know about your other medications and supplements before starting Silenor.

Assess your alertness each morning. If you are not fully alert, do not drive, operate machinery, or perform tasks that require mental sharpness until you feel fully awake.

Silenor side effects

Like all prescription medicines, Silenor can cause side effects, though many people experience none or only mild effects. The most common side effect is drowsiness. Others can include dry mouth, nausea, dizziness, and abnormal dreams. Taking Silenor too close to a meal—especially a high‑fat meal—can increase the chance of next‑day drowsiness.

Serious side effects are rare at low doses but may include urinary retention, worsening of narrow‑angle glaucoma, confusion (particularly in older adults), allergic reactions, or signs of serotonin or anticholinergic toxicity if combined with interacting medicines. Seek immediate care for trouble breathing, severe rash, swelling of the face or throat, or sudden vision pain/blurred vision which could indicate angle‑closure glaucoma.

Antidepressant class warning: Doxepin carries a boxed warning for increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults with major depressive disorder and other psychiatric disorders. Silenor is not approved for use in pediatric patients. Monitor for new or worsening mood changes and contact a clinician if concerns arise.

Common and less common adverse effects

Silenor’s side effects can vary with dose, timing, sensitivity, and other medications. Examples include:

• Common: somnolence/drowsiness, dry mouth, nausea, headache
• Less common: dizziness, fatigue, abnormal dreams, upper respiratory symptoms
• Rare but serious: urinary retention, acute narrow‑angle glaucoma, confusion in older adults, allergic reaction
• Behavioral/psychiatric: new or worsening anxiety, irritability, agitation—seek medical advice if these occur
• Next‑day effects: if you feel sedated the next morning, talk with your prescriber about dose timing or a dose reduction
• Vision changes: sudden eye pain, vision changes, or redness could indicate angle‑closure glaucoma—seek urgent care
• Cardiac: while low‑dose doxepin has not shown clinically relevant QT effects in studies, use caution with other QT‑prolonging drugs

Report any persistent or severe side effects to your healthcare provider. Do not stop or change the dose without professional guidance.

People who are sensitive to medicines with anticholinergic properties should discuss risks with their clinician, even though anticholinergic effects are minimal at Silenor doses compared with higher‑dose tricyclics.

Monitor how you feel when starting Silenor and after any medication changes. Keep a list of any side effects to discuss at follow‑up visits.

Reporting side effects

If you experience side effects, contact your healthcare provider or pharmacist. You can also report adverse events to the FDA’s MedWatch program at www.fda.gov/medwatch or by calling 1‑800‑FDA‑1088. Your feedback helps improve medication safety.

Interaction of Silenor (doxepin) with other medicines

Doxepin is metabolized primarily via CYP2D6. Strong inhibitors of CYP2D6 can increase doxepin levels, potentially intensifying side effects. Combining Silenor with other sedatives may increase CNS depression. Always provide your clinician and pharmacist with an updated list of all prescription drugs, OTC medicines, and supplements.

Medicines that may interact with Silenor include:

• CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, bupropion, quinidine)
• H2 blockers such as cimetidine
• Other CNS depressants (e.g., benzodiazepines, “Z‑drugs,” opioids, certain antihistamines)
• Alcohol
• MAOIs (contraindicated within 14 days)

This list is not exhaustive. Some over‑the‑counter sleep aids, cold remedies, or allergy products contain sedating antihistamines that may compound drowsiness. Ask your pharmacist before combining any products that can cause sedation or anticholinergic effects.

Recommendations from our specialists

Quality sleep is foundational to overall health, mood, and daytime performance. If nighttime awakenings keep you from feeling rested, low‑dose doxepin may be an option. Our specialists recommend a comprehensive approach: start with sleep hygiene and, when needed, consider evidence‑based treatments such as Silenor under a clinician’s care.

Use licensed U.S. telehealth services and pharmacies to obtain Silenor legally and safely. If you are older, take other medications, or have eye or urinary conditions, make sure to review your full medical history with your prescriber. Begin with the lowest effective dose and avoid meals within 3 hours of taking Silenor. Reassess after 1–2 weeks, and adjust therapy based on how you feel.

Ready to sleep better? Order Silenor today!

Take the next step toward restorative sleep. With convenient telehealth options and home delivery from licensed U.S. pharmacies, getting Silenor or generic doxepin has never been easier.

• Clinician‑guided care — U.S. prescription required, with fast telehealth evaluations available
• Fast, discreet shipping across the United States
• Authentic medication sourced from licensed manufacturers and pharmacies
• Competitive pricing on brand and generic 3 mg/6 mg tablets
• Responsive support from pharmacy professionals ready to help

Join thousands of U.S. patients who prioritize sleep health. Discuss Silenor with a clinician, and if appropriate, place your order for convenient home delivery.

Buy Silenor Now